An advertising executive named Roger Thornhill (Cary Grant) has been mistaken for George Kaplan. Spies try to interrogate him to divulging certain information. Roger stumbles upon various obstacles before discovering the reason behind his kidnapping, identity of Eve Kendall (Eva Marie Saint) and the item won by Phillip Vandamm (James Mason).
A advertising exec is chased cross country while he tries to clear his name in a government mistake. In the end, he can't tell who is on his side.